Scientific Challenges

 
Estimated incidence per 100,000 population (2008)
Source: World Health Organization
Confirmed multi-drug resistant TB cases (2008)
Source: World Health Organization
Estimated incidence (2007)
Source: World Health Organization
Estimated TB cases who are HIV-positive(2008)
Source: World Health Organization
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Using the tools of basic science, the KwaZulu-Natal Research Institute for Tuberculosis and HIV seeks new approaches to fighting these deadly diseases.

Scientific Opportunities

K-RITH offers exciting and cutting-edge Masters, PhD and Post-doctoral research programmes aimed at developing the future leaders of science in South Africa.

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Access scientific literature on HIV and TB - a resource designed to serve the HIV and TB research community at the University of KwaZulu-Natal.

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Publications

Rapid sequencing of the Mycobacterium tuberculosis pncA gene for the detection of pyrazinamide susceptibility. - J Clin Microbiol. 2014 Aug 27. pii: JCM.02438-14. [Epub ahead of print]
Multidrug-resistant tuberculosis and culture conversion with bedaquiline. - N Engl J Med. 2014 Aug 21;371(8):723-32. doi: 10.1056/NEJMoa1313865.
The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. - PLoS Comput Biol. 2014 Aug 7;10(8):e1003776. doi: 10.1371/journal.pcbi.1003776. eCollection 2014.
Comparison of Amplicor and GeneXpert MTB/RIF Tests for Diagnosis of Tuberculous Meningitis. - J Clin Microbiol. 2014 Oct;52(10):3777-80. doi: 10.1128/JCM.01235-14. Epub 2014 Jul 23.
Biological differences between the sexes and susceptibility to tuberculosis. - J Infect Dis. 2014 Jul 15;209 Suppl 3:S100-6. doi: 10.1093/infdis/jiu147.
HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck - Science. 2014 Jul 11;345(6193):1254031. doi: 10.1126/science.1254031. Epub 2014 Jul 10.
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. - Biochem Biophys Res Commun. 2014 Jun 20;449(1):114-9. doi: 10.1016/j.bbrc.2014.04.163. Epub 2014 May 9.
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. - J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9.
Effect of Female Genital Schistosomiasis and Anti-Schistosomal Treatment on Monocytes, CD4+ T-Cells and CCR5 in the Female Genital Tract. - PLoS One 2014 Jun 4;9(6):e98593. doi: 10.1371/journal.pone.0098593. eCollection 2014. PMID 24896815.
Consensus standards for introductory e-learning courses in human participants research ethics. - J Med Ethics. 2014 Jun;40(6):426-8. doi: 10.1136/medethics-2013-101572. Epub 2013 Aug 19.
HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. - AIDS Res Hum Retroviruses. 2014 May;30(5):468-75. doi: 10.1089/AID.2013.0197. Epub 2013 Oct 4.
TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. - J Virol. 2014 Apr;88(8):4291-303. doi: 10.1128/JVI.03603-13. Epub 2014 Jan 29.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. - PLoS One. 2014 Feb 3;9(2):e86920. doi: 10.1371/journal.pone.0086920. eCollection 2014.
Neutrophil counts in persons of African origin. - Curr Opin Hematol. 2014 Jan;21(1):50-7. doi: 10.1097/MOH.0000000000000007.
Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection - PLos ONE, 2013 Dec 31; 8(12):e83474. Doi: 10.1371/journal.pone.0083474. (PMID: 234391773)
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study. - Lancet Respir Med. 2013 Dec;1(10):786-92. doi: 10.1016/S2213-2600(13)70231-5. Epub 2013 Nov 21.
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. - PLoS One. 2013 Nov 12;8(11):e77844. doi: 10.1371/journal.pone.0077844. eCollection 2013.
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. - Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46. doi: 10.1164/rccm.201304-0803OC.
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. - PLoS Med. 2013 Oct;10(10):e1001536. doi: 10.1371/journal.pmed.1001536. Epub 2013 Oct 22
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. - Immunity. 2013 Sep 19;39(3):521-36. doi: 10.1016/j.immuni.2013.08.035.
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. - Retrovirology. 2013 Sep 16;10:100. doi: 10.1186/1742-4690-10-100.
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. - PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. - PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013.
Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome. - AIDS. 2013 Aug 24;27(13):2089-99. doi: 10.1097/QAD.0b013e3283614a8d.
Immunohistological characterization of spinal TB granulomas from HIV-negative and -positive patients. - Tuberculosis (Edinb). 2013 Jul;93(4):432-41. doi: 10.1016/j.tube.2013.02.009. Epub 2013 Mar 28.
Structure and interactions of the human programmed cell death 1 receptor. - J Biol Chem. 2013 Apr 26;288(17):11771-85. doi: 10.1074/jbc.M112.448126. Epub 2013 Feb 15.
EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa. - BMC Public Health. 2013 Mar 22;13:258. doi: 10.1186/1471-2458-13-258.
Changes in Natural Killer cell activation and function during primary HIV-1 Infection. - PLoS One. 2013;8(1):e53251. doi: 10.1371/journal.pone.0053251. Epub 2013 Jan 9.
The Physiology and genetics of oxidative stress in mycobacteria - In: Molecular Genetics of Mycobacteria. 2nd edition 2013
Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. - Virology. 2012 Nov 25;433(2):410-20. doi: 10.1016/j.virol.2012.08.033. Epub 2012 Sep 18.
Co-operative additive effects between HLA alleles in control of HIV-1. - PLoS One. 2012;7(10):e47799. doi: 10.1371/journal.pone.0047799. Epub 2012 Oct 19.
Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. - Lab Invest. 2012 Nov;92(11):1541-52. doi: 10.1038/labinvest.2012.125. Epub 2012 Sep 10.
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. - Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15001-5. doi: 10.1073/pnas.1203636109. Epub 2012 Aug 27.
As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs. - Cell Host Microbe. 2012 Aug 16;12(2):132-8. *Corresponding author.
Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. - Mol Microbiol. 2012 Sep;85(6):1148-65. doi: 10.1111/j.1365-2958.2012.08165.x. Epub 2012 Jul 26.
Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis. - Antioxid Redox Signal. 2012 Nov 1;17(9):1232-45. doi: 10.1089/ars.2012.4613. Epub 2012 Jun 13.
Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis. - Curr Opin Chem Biol. 2012 Apr;16(1-2):45-53. doi: 10.1016/j.cbpa.2012.03.004. Epub 2012 Apr 4.
Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. - Antioxid Redox Signal. 2012 Apr 1;16(7):687-97. doi: 10.1089/ars.2011.4341.
Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines. - Antimicrob Agents Chemother. 2012 Jun;56(6):3232-8. doi: 10.1128/AAC.05526-11. Epub 2012 Mar 12.
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. - Blood. 2012 Jan 12;119(2):422-33. doi: 10.1182/blood-2011-05-353789. Epub 2011 Nov 15.
Redox homeostasis in mycobacteria: the key to tuberculosis control? - Expert Rev Mol Med. 2011 Dec 16;13:e39. doi: 10.1017/S1462399411002079.
International Spread of MDR TB from Tugela Ferry, South Africa - Emerg Infect Dis. 2011 Nov;17(11):2035-7. doi: 10.3201/eid1711.110291.
In silico children and the glass mouse model - Antimicrob Agents Chemother. 2011 Feb
The new role of the microchemostat in the bioengineering revolution - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness. - J Virol. 2012 Dec;86(24):13423-33. doi: 10.1128/JVI.02171-12. Epub 2012 Sep 26.
HIV control through a single nucleotide on the HLA-B locus. - J Virol. 2012 Nov;86(21):11493-500. doi: 10.1128/JVI.01020-12. Epub 2012 Aug 15.
January 15, 2015

K-RITH’s proceeds, donated by staff and students towards the beaded ribbon brooches in support of World AIDS Day 2014, were donated to the Hillcrest AIDS Centre Trust Granny Support Groups

December 11, 2014

The Sterlin-2 liquid nitrogen plant was installed in mid-September and started producing liquid nitrogen in early October. The LN2 plant is currently producing liquid nitrogen at a rate of 15 litres per hour. The 2000 litre liquid nitrogen holding vessel is automatically filled with liquid nitrogen once its level drops to 80%.

December 10, 2014

Postdoctoral Research Fellow Jennifer Maroa, K-RITH/MPS Investigator Thumbi Ndung’u and Research Associate Emily Wong attended and each presented a talk at the Federation of African Immunological Societies Conference in Nairobi, Kenya from the 30 November to the 4 December.

December 10, 2014

K-RITH hosted its fourth Interactive Biostatistics Course in November this year.  Lori Chibnik, PhD, MPH, a Biostatistician at Harvard University, facilitated the course, where students work with data from their own projects to understand basic statistical concepts and methods used in medical research.

December 10, 2014

The November K-RITH seminar series had the privilege of having Professor Stewart Cole from the Global Health Institute, Lausanne, Switzerland, speaking about conventional and unconventional approaches to Tuberculosis drug discovery.

January 20, 2015

Director of the Ragon Institute of MGH, MIT and Harvard, Bruce Walker, will be conducting a seminar with five guest speakers, who will be focusing on novel technologies for understanding the human immune response and in vaccine development.

January 16, 2015

Head of the University of the Witwatersrand node of the DST/NRF Centre of Excellence for Biomedical TB Research, Professor Bavesh Kana (PhD), will be hosting the next K-RITH Seminar Series. This Seminar Series will focus on the remodeling of mycobacterial peptidoglycan during growth and tuberculosis disease.

October 17, 2014

Chief Science Officer at the Aurum Institute, Professor Robert Wallis will be the guest speaker for the October K-RITH Seminar.

September 22, 2014

Associate Professor, Muazzam Jacobs, will speak on 'Tumour Necrosis Factor Receptor (TNF-TNFR) interaction - a critical requirement for host immune protection against Mycobacterium tuberculosis infection' for the September K-RITH Seminar Series.

August 29, 2014

Professor Lynn Morris, Chief Specialist Scientist and head of the HIV Virology laboratories within the Centre of HIV & STI’s at NICD will be speaking on 'Prospects for an antibody-based HIV vaccine' at the August K-RITH Seminar.