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Scientific Challenges

Estimated incidence per 100,000 population (2008)
Source: World Health Organization

Confirmed multi-drug resistant TB cases (2008)
Source: World Health Organization

Estimated incidence (2007)
Source: World Health Organization

Estimated TB cases who are HIV-positive(2008)
Source: World Health Organization

TB
MDR-TB
HIV
HIV + TB

Using the tools of basic science, the KwaZulu-Natal Research Institute for Tuberculosis and HIV seeks new approaches to fighting these deadly diseases.

Scientific Developments

Outstanding Masters Students Wanted

Are you a high achieving student of the extraordinary with an honours degree in the Mathematical, Engineering or Biological sciences? Then we need to talk to you.

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Comment & Analysis

Did you know that Mtb scavenges iron from its host in order to intensify the infection. K-RITH post-doc Ryan Wells has taken another look at the mechanism the bacteria uses to extract iron from the host.

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Publications

Drug Resistant tuberculosis, KwaZulu-Natal, South Africa, 2001-2007. Emerg Infect Dis. 2011 Oct.

Environmental heme-based sensor proteins: Implications for understanding bacterial pathogenesis. Antioxid Redox Signal. 2012 Jun 13.

Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis. J Antimicrob Chemother. 2012 Feb.

In silico children and the glass mouse model Antimicrob Agents Chemother. 2011 Feb.

Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. Antioxid Redox Signal. 2012 Apr 1.

Iron sulfur cluster proteins and microbial regulation. Curr Opin Chem Biol. 2012.

Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. PNAS. 2012.

Mycobacterium tuberculosis Directs T Helper 2 Cell Differentiation by Inducing Interleukin-1β. J Biol Chem. 2012 Jul 18.

Isoniazid resistance without a loss of fitness in Mycobacterium tuberculosis. Nat Commun. 2012 Mar 20.

Mycobacterium tuberculosis WhiB4 regulates oxidative stress response. Mol Microbiol. 2012 Jul 11.

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K-RITH News

AECM Study Finds Vitamin C Can Kill Drug-Resistant TB

May 22, 2013

In an unexpected turn of events, researchers at Albert Einstein College of Medicine of Yeshiva University announced yesterday that they have determined that vitamin C kills drug-resistant tuberculosis (TB) bacteria in laboratory culture.

Students Hungry for Biostatistics

April 26, 2013

K-RITH’s second biostatistics course, hosted for the first time in the new K-RITH Tower Building, left students asking for more, and I don’t mean more of the Smarties and M&Ms that they were counting for their chi square test! No, it seems that the only thing that these students were hungry for was to learn more statistics!

VC of K-RITH's Founding Partner to receive Presidential Award

April 25, 2013

UKZN’s Vice-Chancellor and Principal, Professor Malegapuru Makgoba, and the Associate Scientific Director of Caprisa and renowned HIV/AIDS and TB researcher, Professor Quarraisha Abdool Karim, will receive national awards of commendation from President Jacob Zuma at the weekend.

Key Dates & Events

7th International Conference on Fe-S Cluster Biogenesis and Regulation

May 20, 2013 - May 24, 2013

K-RITH Investigator Adrie Steyn will be speaking at the 7th International Conference on Fe-S Cluster Biogenesis and Regulation.

Mycobacterial Genetics Course

July 1, 2013 - July 12, 2013

Are you a final year BSc, Honours, Masters or medical student? Join us in an exciting adventure to discover new bacteriophages that might contribute towards the treatment of tuberculosis.

K-RITH Research Lecture Series

May 8, 2013

Markus Maeurer, Professor of Infectious Disease Control, Karolinska Institutet, Sweden will talk on "Stem cell immunotherapy for TB"